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[DOI] [Google Scholar] 14.Rauzier J, Moniz-Pereira J, Gicquel-Sanzey B
Homocysteine, age-related cognitive impairment and dementia Technological advances in homocysteine measurement not only enabled large-scale epidemiological studies of associations with vascular disease, but also heralded an avalanche of literature describing its association with age-related cognitive impairment, including Alzheimers disease (AD) and dementia (53, 54)
Sheldon AL, Gonzalez MI, Robinson MB

Indeed, in addition to HbS polymerization, an imbalance in redox status is also seen in SCD, which is caused by a rise in ROS and/or RNS generation coupled with a malfunction in the antioxidant systems
It then systematically details the specific mechanistic architectures that define each pain subtype, explaining how tissue injury, nerve damage, and maladaptive central processing translate into unique clinical experiences (Figure 2)

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