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[DOI] [PMC free article] [PubMed] [Google Scholar] Huang Y., Ren Q

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In summary, CDC42, derived from neural stem cell-derived exosomes, as well as TIGAR, FTO, and IRP2, contribute to PD pathology by regulating iron homeostasis, ferroptosis, fatty acid metabolism, the antioxidant system, and angiogenesis

However, due to the lack of long-term observation of GSH depletion and in vivo animal experiments, it is difficult to evaluate whether ferroptosis is a bona fide autophagy activation process or a prerequisite for autophagy activation process

A 2020 double-blind, placebo-controlled study in Dermatology Practical & Conceptual showed that glutathione significantly improved skin elasticity, reduced wrinkles, and brightened skin tone over the course of 12 weeks