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Apart from its immune suppressive effects in CD8 + T cells [197], methylglyoxal also promotes TAMs polarization and breast, colon, and liver tumor cells growth [198]

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Researchers have also linked altered barrier function to disorders including irritable bowel syndrome and food allergies, and the association between high permeability and inflammatory conditions is an active, legitimate area of study

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The bottleneck logic is worth restating because it explains when stacking helps at all: adding a second compound only matters if it clears a different rate-limiting step than the ones already covered