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Elevated alpha-synuclein caused by SNCA gene triplication impairs neuronal differentiation and maturation in Parkinsons patient-derived induced pluripotent stem cells
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On the other hand, copper deficiency could impair the activity of several copper-containing antioxidant enzymes, suggesting that copper deficiency, as well as excess, could increase the risk of atherosclerosis
However, environmental factors are required for the development of manifest disease
