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Results Adipocyte-specific Ssu72 deficiency is resistant to HFD-induced obesity To investigate the potential role of Ssu72 in metabolic homeostasis, we initially compared Ssu72 expression in visceral adipose tissue (vWAT) between lean and obese individuals or mouse models from Gene Expression Omnibus (GEO) public database

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Role of Myeloid-derived suppressor cell (MDSC) in autoimmunity and its potential as a therapeutic target

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A persistent stimulation of endometriotic tissues with TGF-1 was able to reduce NR4A1 activity through AKT-dependent phosphorylation, promoting fibrogenesis in OMA [34] and the treatment with Csn-B, an NR4A1 agonist, markedly decreased the expression of fibrotic markers in vitro and inhibited fibrogenesis in urine endometriosis models, suggesting a new potential target for the treatment of this disease [34]