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Through bypassing traditional copper-binding proteins, they may restore copper homeostasis within the CNS without affecting systemic copper levels

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Acne-fighting drugs contain the female sex hormones estrogen and progestin

The absence of standardized analytical methodologies, variability in phytochemical profiles across ecotypes, and limited regulatory frameworks for functional claims further restrict their integration into functional food sectors, pharmaceutical formulations, and nutraceutical industries

Biosci Biotechnol Biochem 61(12):19771980 Van Der Werf P, Orlowski M, Meister A (1971) Enzymatic conversion of 5-oxo-L-proline (L-pyrrolidone carboxylate) to L-glutamate coupled with cleavage of adenosine triphosphate to adenosine diphosphate, a reaction in the -glutamyl cycle

The collective perspective is that TrxR can be targeted through new drug development with the aim of impacting predominately Gram-positive and glutathione independent bacteria
