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Left unmanaged, this imbalance is what's called oxidative stress , and it's been linked to everything from premature skin ageing to long-term organ strain

These peripheral clocks coordinate organ-specific functions, including glomerular filtration (Song et al., 2024), tubular reabsorption (Bignon et al., 2023), and electrolyte excretion (Costello et al., 2025) in the kidneys, as well as intraocular pressure (IOP) regulation (Ikegami et al., 2020), tear secretion (Huang et al., 2025), and photoreceptor maintenance in the eyes (Fagiani et al., 2022

The American Journal of Psychiatry 157(5):715721

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Ferroptosis, an iron-dependent form of programmed cell death driven by lipid peroxidation, holds therapeutic potential
