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Graphical abstract Access this article Similar content being viewed by others Abbreviations ACh: Acetylcholine AChE: Acetylcholinesterase AD: Alzheimers disease ApoE: Apolipoprotein E APP: Amyloid precursor protein A: -Amyloid A42: Amyloid-42 BBB: Blood-brain barrier BMP9: Bone morphogenetic protein 9 CFC: Chlorofluorocarbons CNS: Central nervous system CSF: Cerebrospinal fluid DNA: Deoxyribonucleic acid DTE: Drug targeting efficiency DTP: Drug transport percentage EMA: European Medicines Agency FDA: Food and Drug Administration FID: Fluorescein isothiocyanate dextran HFA: Hydrofluoroalkane NSAID: Non-steroidal anti-inflammatory drug PACAP: Pituitary adenylate cyclase activating polypeptide PET: Positron emission tomography PLGA: Poly(lactide-co-glycolide) acid PLA: Polylactide SLN: Solid lipid nanoparticles TFB: Tarenflurbil TMME: Tacrine mucoadhesive/microemulsion References Chen WW, Zhang X, Huang WJ