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Francardo V, Geva M, Bez F, Denis Q, Steiner L, Hayden MR, et al
Dev Cell 22(4):707720
Recently, another selective inhibitor of GLS1, CB-839 (telaglenastat), showed no significant side effects in preclinical trials and is currently undergoing full clinical trials 45
The mutations of IDH1 or IDH2 exhibit a neomorphic activity by converting glutaminederived KG to 2hydroxyglutarate (2HG), which competitively inhibits KGdependent histone and DNA demethylases (Dang et al , 2010
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