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doi: 10.1016/j.niox.2019.02.001 150 HedlundPAszdiAPfeiferAAlmPHofmannFAhmadMet al

Abstract Depression is a common psychiatric disorder

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In addition, CBN, CBG, CBC, CBDV, and THCA prevented oxytosis, which in the case of CBN, was later confirmed to be via direct targeting of mitochondria and promotion of antioxidant defenses, indirectly of CB receptors (Liang et al., 2022)

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Conversely, it was observed that excessive accumulation of mitochondria Ca 2+ led to mitochondrial rupture and a decline in mitochondrial function in Lysosomal storage-diseases (LSDs) (Cantarero et al., 2021), suggesting that mitochondrial biogenesis can be inhibited as a protective mechanism in cells and tissues when lysosomes are defective (Khalil et al., 2017), indicating that lysosomes and mitochondria are interdependent and coordinate across time and space barriers, to complete complex cell metabolism, signal transduction, and other functions to maintain the homeostasis of the whole cell (Qing-long, 2022)