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Pumping, especially using modern pumps with customizable settings, effectively mimics the mechanical aspects of infant suckling 32 , thus encouraging a similar positive feedback loop that sustains milk production while removing direct nipple contact between mother and infant
Firstly, our study further strengthen the evidence of well-designed RCTs of ALC in HE and introduce the view and methodology of evidence-based medicine (EBM) when compared with a previous review included 3 clinical trials reported in 2008.28 Secondly, perhaps more and more investigators from different countries will be interested and highlight the role of ALC and conduct studies with far more important findings, so as to provide another choice drug for HE
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Martinez-Amezcua P, Dooley EE, Reed NS, et al
The most common type used in UK pharmacies is hydroxocobalamin , which is the version recommended by the NHS for treating B12 deficiency
However, a 2017 trial highlights some of the opportunities for future exploration and suggests that patients could realize therapeutic benefits
The hypothalamic-pituitary-gonadal Axis
