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Astrocytes also regulate the neuronal excitability by modulating tonic N -methyl-D-aspartate (NMDA) receptor currents, by releasing glycine and contributing to extracellular level of D-serine, both being allosteric co-agonists of NMDA receptors through the release of glutamate and contributing to extracellular levels of NMDA receptors 82,83

Journal of Biological Chemistry, 280 (37), 3225432261

ER is extensively present in mouse skeletal muscle, and it is posited that estrogen may enhance muscle endurance by modulating muscle fiber composition via the ER signaling pathway (24)

These antioxidant drugs could be used for the treatment of various pathological diseases, and therefore gained importance in clinical as well as research areas

FIGURE 1 2.1.6.1 HIF1 and VEGF Most experiments suggested that HIF1 is overexpressed in OSA-associated lung cancer (Huang et al., 2020)

Another potential cause of this phenomenon is high leptin levels, typically found in these patients [62]