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Lounder, D

longum ) reduces their excitability [102-104]

They represent signalling domains found along the ECM protein chains and are capable of interacting with receptors on the cellular membrane

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These matrix changes may render the degenerated IVD as a more brittle stiffer tissue with less dynamic compliancy properties under load and more prone to the development of fissures in the IVD, further compromising its normal biomechanical functions (Vergroesen et al., 2015)