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JCI Insight 2020;5:e131277

This oxidative stress and mitochondrial dysfunction form a reciprocal relationship, perpetuating a vicious cycle

And ketamine poses significant risks for Veterans if they have a history of PTSD, traumatic brain injury [TBI], psychosis, or substance use. Ketamine, which is administered intravenously, is an established anesthetic for surgery and diagnostic procedures

Moreover, studies using isolated mitochondria from rat skeletal muscle found that ROS production occurred at 11 sites associated with substrate oxidation and oxidative phosphorylation 9

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