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Interestingly, A6 enhanced recovery of ischemia-injured jejunum at a 10-fold lower dose (0.1 M) than the effective dose of LA in the same injury model (50)

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This strategy ideally enables receptor-mediated transcytosis (RMT) across the BBB via TfR functionality, while cRGD targets integrins overexpressed on the inflamed BBB and neurovascular units proximal to A aggregates