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Plasma levels higher than this range are classified as mild/moderate, intermediate, or severe hyperhomocysteinemia2: mild/moderate: 15 to 30 mol/L

Accessed 3 Nov

As the precise pathological mechanisms of PD remain incompletely understood, current treatments mainly rely on pharmacological modulation of neurotransmitters in the brain

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First, although SLC30A10 mediates the release of Mn from the brain and SLC39A8 facilitates its uptake 312 , the precise mechanisms that regulate neuronal Mn transport and accumulation remain poorly understood