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Stimuli-Responsive Systems Stimuli-responsive systems release drugs in response to environmental cues, such as low pH (~6.0 in inflamed joints), high ROS, or enzyme activity

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this is because the body does create its own supply from the amino acids: L-cysteine L-glutamic acid Glycine One of the reasons why Glutathione is so important for optimum health is that its present in every cell in the body

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Ferroptotic cell death results in the release of different DAMPs (e.g., high-mobility-group box 1) or lipid peroxidation products (e.g., 4-HNE) (52), which can further activate inflammation and the corresponding oxidative injury