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Additionally, it is possible that endotoxin and inflammation by gut flora may contribute to increased uptake of ammonia from gut into the bloodstream and thereby contribute to the latters toxic effect on the liver [132]

doi: 10.3389/fphar.2023.1142001 62 MittalMSiddiquiMRTranKReddySPMalikAB

Another mechanism would be an elevation in endogenous diacylglycerol (DAG) levels which can activate tyrosine kinase-inducing melanogenesis (Videira et al., 2013)

2018 Feb 16;5(2):25

Hyperoxic Vasoconstriction of Human Pulmonary Arteries: A Novel Insight into Acute Ventricular Septal Defects