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Microneedling increases absorption 10-fold

Research indicates that it enhances collagen synthesis and supports the remodeling of the extracellular matrix, making it valuable for treating skin wounds and burns

[DOI] [PMC free article] [PubMed] [Google Scholar] 2.Shanina E, Liao B, Smith RG

An alternative folate- and vitamin B12-independent reaction utilizes betaine (a metabolite of choline) as the methyl donor to convert homocysteine to methionine

It acts in the dermis of the skin to stimulate fibroblasts to produce more collagen, elastin, proteoglycans, and glycosaminoglycans, resulting in fuller, more elastic skin