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It may be promising, but it is not yet proven.

All compounds were tested at the concentration of 10 M

Hypothalamus production of thyrotropin-releasing hormone (TRH) stimulates anterior pituitary gland to secrete thyroid-stimulating hormone (TSH), which affects thyroid gland and leads to production of thyroid hormones

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Notably, HIF-1 mediates adaptive metabolic responses to hypoxia by enhancing glycolytic pathway, serine synthesis and one-carbon metabolism to promote mitochondrial antioxidant production (NADPH and GSH), and inhibiting the TCA cycle so as to diminish mitochondrial ROS production (247)