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Int J Obes 26(6):754764 Lucotti P, Monti L, Setola E, La Canna G, Castiglioni A, Rossodivita A et al (2009) Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass

doi: 10.1038/s41574-024-01072-x

Given the rich lipid content of the nervous system, hemoglobin-derived iron works with lipid peroxidation to induce ferroptosis, which eventually leads to neuronal mitochondrial damage, edema, and apoptosis of neurons and astrocytes

10.1021/acsnano.4c15283 121

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1 Read at the right altitude, these are illustrations of why the mechanism is plausible, not a complete account, and certainly not human proof
