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Complete loss of neurofibromin activity, caused by second hit mutations, leads to hyperactivation of Ras signaling and tumor onset

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Puerarins anticancer effects may be carried out through PI3K/AKT/mammalian target of rapamycin (mTOR), Ras-Raf-MEK-ERK, JNK, AMPK, and NF-B pathways ( 5.10 Other activities With the help of the STRING database ( and Cytoscape 3.8.2 software ( the targets described above were visualized (Figure 10)

Phytother Res 33:22212243 Esposito C, Santarcangelo C, di Minno A et al (2022) Chemical characterization and preliminary evaluation of the efficacy and tolerability of a food supplement based on pomegranate extract, B vitamins, and vitamin C against prolonged fatigue in healthy consumers