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As a result, EC may function as a sentinel malignancy, serving as an early indicator of LS in affected individuals and facilitating the identification of at-risk family members through genetic screening and surveillance (38, 112)

Aging and chronic ailments like diabetes decrease the ability of the kidneys to recover from injuries, resulting in chronic kidney disease (CKD)

Dietary ascorbate is also involved in non-heme iron absorption in the small intestine and in the overall regulation of iron homeostasis

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Histamine stimulates vasodilation and increased capillary permeability, resulting in the classic allergic symptoms of runny nose and eyes

doi: 10.1016/j.cell.2021.01.015 61