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To make the injection painless, a topical numbing cream can be applied 1 hour prior to treatment, but normally there is minimal discomfort

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The tools with the strongest evidence for anxiety and mood support include consistent sleep (seven-plus hours, regular schedule), regular physical activity (both resistance training and cardiovascular exercise have demonstrated antidepressant and anxiolytic effects), therapy or coaching for cognitive and behavioral patterns, mindfulness or stress-management practices, and social connection