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Ojumah, Naomi, Marios Loukas, and R

Regenerative medicine as a new branch of medical science has developed rapidly in recent years

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Moreover, human SIRT1 and AMPK cooperatively induce autophagy by upregulating autophagic genes and by inhibiting mTOR signaling [89]

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The analysis of in vitro release kinetics results obtained a better adequacy by means of the mathematical model Korsmeyer-Peppas, reaching in this, respectively for AmB w/Gel and NLC w/AmB-Gel, the highest R2 (0.904 and 0.986), the lowest AIC (23.476 and 32.106) and the highest MSC (1.932 and 3.761), with the release exponent (n) of 0.319 and 0.495, according to Table 8