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During pregnancy, oxidative stress can impair mitochondrial function in fetal neural tissues

Therefore, the following MBMA analysis was mainly aimed at l-carnitine

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Further, PGC-1 knockdown reduces basal hepatic glucose output and improves liver insulin sensitivity, which was attributed to an increase in insulin-stimulated phosphorylation of AKT in db/db diabetic mice (165)

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More high-throughput screens have been used to identify new classes of compounds, such as the glycerol ethers niphatenones isolated from the sponge Niphates digitalis, which are proposed to covalently bind the AF1 and may serve as lead compounds for further drug development 180