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[DOI] [PubMed] [Google Scholar] 31.Rzga M, Bal W

The sites IGF-1 LR3 mechanism and research overview expands on this profile

Other proteins that bind KEAP1 and interfere with KEAP1-NRF2 interaction, promoting NRF2 accumulation and function in the nucleus, include: phosphoglycerate mutase 5 (PGAM5, a serine/threonine phosphatase related to the phosphoglycerate mutase family), which has been reported to be associated with mitochondria, so its interaction with KEAP1 may be regulated by mitochondrial signalling processes [187, 188]

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In the largest series reported, polygraphic videoEEG recordings revealed that myoclonic seizures consisted of axial jerks with head drop, elevation and extension of both arms, flexion of the legs, and upward gaze