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References 1 AbdrakhmanovA.KulikovA.LuchkinaE.ZhivotovskyB.GogvadzeV

pylori infection in North America. Using Grading of Recommendations, Assessment, Development and Evaluation methodology, Chey and colleagues evaluated options for treatment-naive and treatment-experienced patients and analyzed 11 population-intervention-comparison-outcome questions, from which 12 recommendations were generated

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Furthermore, inflammation upregulates cyclo-oxygenase-2 (COX-2) activity, thus increasing the synthesis of prostaglandins (PGE) [7] and the release of pain-related neuropeptides [56]

However, these reports often lack detailed methodologies, making it difficult to assess the true impact of the peptide

These data are preliminary and derive from bioinformatics analyses, but they form the basis for further in vivo studies