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Maintenance Treatment Following First-line ALIMTA Plus Platinum Chemotherapy The efficacy of ALIMTA as maintenance therapy following first-line platinum-based chemotherapy was also evaluated in PARAMOUNT (NCT00789373), a multi-center, randomized (2:1), double-blind, placebo-controlled study conducted in patients with Stage IIIb/IV non-squamous NSCLC who had completed four cycles of ALIMTA in combination with cisplatin and achieved a complete response (CR) or partial response (PR) or stable disease (SD)

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Razavi et al., 2021

CD8 + cytotoxic T lymphocytes mediate direct thyrocyte lysis via perforin, granzymes, and proteoglycans, and are recruited and activated by autoreactive CD4 + T cells through IL-12 and IFN- signaling