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A distinct sequence (ATAAA)n separates methylated and unmethylated domains at the 5-end of the GSTP1 CpG island

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Key amino acids (lysine, methionine, arginine, cystine, tryptophan, glutamine, aspartate, proline, BCAAs) modulate HCC malignant phenotypes

The IVD and ACAD8 encoded proteins are involved in the catabolism of leucine and valine, respectively

De Santis et al

The importance of this finding is highlighted by the fact that GWAS utilizes a less biased approach by first detecting, among a large pool of candidate SNPs, those SNPs that strongly correlate with disease risk or progression