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Whereas in normal conditions penile erection is mediated by the action of the two constitutive enzyme forms, neuronal (nNOS) and endothelial NOS (eNOS), which cause normal NO amounts to be produced, in pathological conditions and in PD high local nitric oxide radical (NO ) concentrations occur, due to mediation of the inducible enzyme form (iNOS) [34]

Transport of extracellular l-arginine via cationic amino acid transporter is required during in vivo endothelial nitric oxide production

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