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Beyond its involvement in transcriptional elongation, H3K36me3 also plays an essential role in maintaining transcriptional fidelity by preventing inappropriate transcriptional initiation and suppressing spurious transcriptional activity, through interaction with DNMT3A and DNA methylation (Dhayalan et al., 2010

10.1038/s41467-019-14279-8 122 ReportA.S.A.(2024)

These inhibitors differ based on which of the two DPP-4 structural classes they belong to (non-peptidomimetics or dipeptide structural mimics), their metabolism (liver vs