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Four key mechanisms have been identified that are thought to contribute to MDMA neurotoxicity and these include (1) hyperthermia, (2) MDMA metabolism, (3) oxidative stress, and (4) dysregulation of energy metabolism via mitochondrial dysfunction

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The Journal of Clinical Endocrinology & Metabolism, 104(10), 44714486
doi: 10.2174/1381612013397203 96 OkuTTjuvajevJGMiyagawaTSasajimaTJoshiAJoshiRet al

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