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Wh-ereas the three studies finding a significant therapeutic efficacy of the COX-2 inhibitor were based on patients with a short illness period,113114115 the one study with a negative result was conducted with patients with relatively chronic schizophrenia.116 A meta-analysis showed that augmentation of anti-inflammatory drugs to the antipsychotics would be a potential therapeutic options in patients with schizophrenia, although more evidences should be accumulated.117 Several antioxidant treatment approaches have reported that antioxidants are effective for improving psychopathology in schizophrenia

In addition to the application of exogenous substances to produce a regulatory effect on mitochondrial metabolism, the direct repletion of metabolites opens a new therapeutic chapter

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