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Description
just like chlamydocin, it contains a 6-oxo-7,8-epoxyoctyl side chain which serves as the Zn 2+ -coordinating group and its ketone carbonyl group is isosteric with the scissile carbonyl of the HDAC substrate acetyl-L-lysine, acting like an irreversible class I HDACi [81]

[DOI] [PubMed] [Google Scholar] 120.Cohen P.A

Ali Alshehri S, Alsayari A, Wahab S, Alqarni H, Sweilam M, Khalid SH

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B-ENT (2013).9(2), 111-116

Beck, I
