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Drusen Proteome Analysis: An Approach to the Etiology of Age-Related Macular Degeneration

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Ashton-Miller, J

This condition results from disruption in glucose metabolism, often stemming from insufficient insulin production by the pancreas, reduced in insulin effectiveness in body tissues (insulin resistance), or a combination of these factors, which is particularly common among older adults [556]

Though discrepancy exists under these conditions, a common requirement of Ca 2+ necessitates PAD4 activation through the pore-forming proteins, such as MLKL, GSDMD and GSDME 53,54,55,56

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