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With gadolinium-based contrast agent administration, fibromas generally show no contrast enhancement during perfusion imaging due to avascularity

When secondary to melanocyte proliferation, it shows a brownish- black color and it is due to melanocytic nevus (MN), lentigo simplex, atypical melanocytic hyperplasia, or melanoma.2 While approximately 5% of LM in adults correspond to melanoma, it is typically benign in childhood, with MN being one of the major causes, but it shares clinical, dermoscopic, and histopathological features with subungual melanoma.3,4 Nail matrix biopsy is the gold standard for etiological diagnosis, but it is an invasive procedure, difficult to perform in children, often complicated by nail dystrophy and recurrence, which makes the decision between clinical follow-up and biopsy to be challenging

33(5): 8535 Barone GW, Gurley BJ, Ketel BL, et al

A., Graveley, B

Lower lip: More sun exposure Common site for melanotic macule Upper lip: Often linked to hormonal pigmentation Understanding where your dark black spot on lip appears helps narrow possible causes

Once this critical transport mechanism is restored, the mitochondria can resume beta-oxidation, converting those dormant, accumulated fats into a steady, reliable stream of ATP