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Gene Ontology analysis (GO) of these DEGs further revealed significant enrichment of terms associated with plant defense signaling, including defense response, cellular responses to JA, response to wounding, and response to hormone (Fig

3 One of the significant challenges when implementing a soft-spot analysis approach is the ability to produce data promptly in alignment with the pace of the drug discovery process

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Efforts in this area have led to the identification of potent mimics of cytokines interleukin-2 (IL-2) and IL-15 78 , programmed cell death protein-1 (PD-1) agonists 79 , and SARS-CoV-2 inhibitors 80 , among others 81,82

[DOI] [PMC free article] [PubMed] [Google Scholar] 147.Xiao W, Jiang W, Chen Z, Huang Y, Mao J, Zheng W

7c,d, Extended Data Fig