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Chem Phys Lipids (2019) 221:4652

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(6) In the context of radiotherapy for cancer patients, how might ferroptosis be regulated to mitigate the adverse effects of radiotherapy without compromising its tumor-killing efficacy

It is transformed in the bloodstream into the active metabolite 3-methyl-(triazen-1-yl) imidazole-4-carboxamide, which donates a methyl group to some DNA bases (chiefly guanine), resulting in an erroneous matching of O 6 -methylguanine with thymidine during DNA replication

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