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Factors that Contribute to Knee OA Knee OA typically develops after age 50, although it can begin earlier, and women are up to twice as likely to develop the condition

The gut microbiota and its relevance to peripheral lymphocyte subpopulations and cytokines in patients with rheumatoid arthritis

Clostridium butyricum-induced balance in colonic retinol metabolism and short-chain fatty acid levels inhibit IgA-related mucosal immunity and relieve colitis developments

Thus, goblet cells can differentially regulate the mucus barrier and the delivery of luminal antigens to the immune system (FIGURE 7)

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