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TNF-, as a key proinflammatory factor, activates NF-B and MAPK signaling pathways by binding to its receptors TNFR-1 and TNFR-2 (Liu et al., 1996

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Hereditary causes include genetic defects in the metabolism of amino acids, cholesterol, and fatty acids, such as propionyl-CoA carboxylase deficiency (aka propionic acidemia) and medium chain acyl-CoA dehydrogenase deficiency (36)
