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These models are most frequently initiated in larvae, primarily due to their optical transparency, which permits non-invasive real-time imaging of pathological processes, their small size enabling high-throughput screening, and their rapid developmental timeline

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Their dysregulation perpetuates airway inflammation and may be associated with disease severity-phenotype and future risk of exacerbations.16,21,22 On the other hand, although it is not a biomarker per se, bacterial load shows a direct correlation with levels of local and systemic markers, and plays an important part in the pathogenesis of bronchiectasis