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However, under oxidative stress, Bach1 dissociates from the HO-1 promoter, and stress signals induce the dissociation of Nrf2 from Kelch-like ECH-associated protein 1 (Keap1), which then binds to AREs and initiates the downstream expression of oxidative stress-resistant HO-1 to prevent ROS-induced cellular damage and maintain the organisms antioxidant response (Zhang et al., 2019)

Neurones in the arcuate melanocortin system, particularly those that produce proopiomelanocortin (POMC)-derived peptides, play a significant role in T2DM [82, 83]

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It needs to be emphasized that this strategy should be applicable to any cell surface protein of sorting pathway, regardless of physiological activity of targeting proteins