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Brain cells are vulnerable to oxidative stress, which damages DNA and proteins and could contribute to cognitive decline and dementia

Therefore, treatments with CD28-targeted CAR T cells are considered bridging therapies, and HSCT is generally planned for eligible patients 4 to 8 weeks after the CAR T-cell procedure

10.1002/(SICI)1098-1004(200003)15:3 3.0.CO;2-3

Unfortunately, current hiPSC modeling methods fall short in accurately mimicking the interactions between the diseased cell type and other cells within the tissue or the patients body

Specifically, apoptosis is executed by activation of effector caspases such as CASP3 and CASP7, occurring downstream of initiator caspases CASP8, CASP9, and CASP10
Osteophyte formation was also reduced in DMM-operated Igf1 CART-KO mice compared to DMM-operated controls (Fig
