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The levels of evidence are based on the possibility of change in the estimate of clinical effect by further research and are described as high (A), moderate (B), or low (C)
2018 Feb/Mar;80(2):154-159

The NPC1 protein, a multiple transmembrane protein located on LE/Ly, is primarily responsible for the egress of cholesterol from lysosomes to other cellular compartments in mammals (37, 38, 39)
Increased tear osmolarity in dry eye disease has been found to stimulate production of inflammatory cytokines and matrix metalloproteinases by ocular surface epithelial cells [155]

L- : ( 90 140 100 )
2022 Previous acne treatments and response, as well as specific adverse effects and adherence issues, should be evaluated