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Description
Haematological symptoms typically appear first and include fatigue, weakness, and pallor due to megaloblastic anaemiaa condition where the bone marrow produces abnormally large, immature red blood cells that function poorly

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The latter is a potent but non-selective S1P receptor agonist, binding with similar affinity as S1P to S1P 1 , S1P 3 , S1P 4 and S1P 5 , but not S1P 2 [77]
Vitamin B12

Serious B12 deficiency may cause anemia and nerve damage

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