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These inconsistencies pose challenges in comparing studies, establishing definitive doseresponse relationships, and extrapolating results from rigorously characterized preparations used in clinical trials to the heterogeneous products accessible to consumers (569)

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Additionally, mitochondrial DAMPssuch as mtDNA, N-formyl peptides (fMLP), cardiolipin, and ATPreleased during lung injury, induce proinflammatory responses via NF-B and MAPK pathways (Fig

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