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doi: 10.1038/ajg.2009.719

ADSCs, miR-423-5p-modified ADSCs (miR-ADSCs), and negative control ADSCs (NC-miR-ADSCs) were co-cultured with human umbilical vein endothelial cells (HUVECs) under normal and high glucose conditions, and eNOS and VEGFa expression, cell proliferation, and apoptosis were measured

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A comparative study showed that the chemically induced hepatocytes resemble growth-factor derived counterparts ( Despite the progress made in chemical induction of hepatocyte, it is noteworthy to mention that consensus on optimal small molecule combinations, doses and hepatocyte quality is lacking, hindering protocol standardization and clinical translation
This condition differs from tolerance, which is the need for increasing doses of opioids to maintain a defined effect [see Dependence]
