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Selenium compounds and their bioactivities: molecular mechanisms and prospects for functional food and therapeutic applications

That rationale must be backed by non-clinical data confirming the compound behaves as expected and by a thorough safety and toxicology program that identifies potential risks and establishes a safe starting dose for the first human administration and the maximum human exposure that should not be surpassed

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The gut microbiota has also been demonstrated to influence sex hormone levels by modulating sex hormone-related enzymes and enterohepatic circulation, impacting the hypothalamic-pituitary-testicular axis and promoting sexual arousal and behaviour [216]

A role for glutathione transferase Omega 1 (GSTO1-1) in the glutathionylation cycle

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