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doi: 10.1210/jc.2012-4203 166 ChenYCTaylorAJFulcherJMSwensenACDaiXQKombaMet al
233 Upon escalating the dose to 0.17 mg m 2 day 1 , severe myelosuppression and gastro-intestinal toxicity were observed
PMID 10855708

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Testing a drug's safety profile and metabolism in a small group of disease-free individuals is the hallmark of Phase 1

Louis, MO, USA) while U87 and U87-EGFRvIII cell lines were maintained in EMEM medium (Lonza, Levallois Perret, France)
